drug_type
RELEVANT_DRUG
intervention_type
Antibody-drug conjugate
drug_description
HER2-targeted antibody-drug conjugate that binds HER2, is internalized, and releases MMAE (a microtubule inhibitor) to induce cytotoxicity with potential bystander effect.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Disitamab Vedotin
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
HER2-targeted antibody-drug conjugate that binds HER2 on tumor cells, is internalized, and releases the microtubule inhibitor MMAE after linker cleavage, causing microtubule disruption, G2/M cell-cycle arrest, and apoptosis; membrane-permeable payload enables a bystander killing effect.
drug_name
Disitamab vedotin (RC48)
nct_id_drug_ref
NCT05847764