10-1074-LS is a human IgG1 broadly neutralizing monoclonal antibody that binds the HIV-1 Env gp120 V3-glycan supersite, neutralizing diverse virions and blocking gp120 engagement with CD4 and co-receptors to prevent viral entry. LS Fc mutations enhance FcRn binding and extend serum half-life. Through Fc effector functions (e.g., ADCC/ADCP), it may also promote clearance of Env-expressing infected cells.