drug_type
RELEVANT_DRUG
intervention_type
Antibody-drug conjugate
drug_description
An antibody-drug conjugate comprising a fully human anti–Nectin-4 monoclonal antibody linked to exatecan; it binds Nectin-4 on tumor cells, is internalized, and releases exatecan to inhibit topoisomerase I, causing replication-associated DNA damage and tumor cell death.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibody-Drug Conjugates
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Fully human anti-Nectin-4 monoclonal antibody linked to exatecan; binds Nectin-4 on tumor cells, is internalized, and releases exatecan to inhibit topoisomerase I, trapping Topo I-DNA complexes and causing replication-associated DNA damage and tumor cell death.
drug_name
BAT8007
nct_id_drug_ref
NCT05879627