drug_type
RELEVANT_DRUG
intervention_type
Biological (cellular therapy)
drug_description
Allogeneic cord blood–derived natural killer cells genetically engineered to express a chimeric antigen receptor targeting CD70, designed to bind CD70 on tumor cells and induce NK-mediated cytotoxicity while potentially modulating the CD70/CD27 pathway in CD70-positive T-cell lymphoma and acute myeloid leukemia.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Killer Cells, Natural
drug_category
CAR NK
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Allogeneic cord blood–derived NK cells engineered to express a CD70-directed chimeric antigen receptor bind CD70 on tumor cells, triggering NK activation and cytotoxic killing (perforin/granzyme) of CD70-positive cells and potentially disrupting CD70/CD27 signaling in TCL and AML.
drug_name
CD70 CAR-NK
nct_id_drug_ref
NCT06696846