drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy
drug_description
Allogeneic cord blood–derived NK cells engineered to express a CD70-targeted chimeric antigen receptor and an IL-15 transgene to support survival, proliferation, and persistence; designed for antigen-specific cytotoxicity against CD70-expressing tumors.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
CAR NK
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Allogeneic cord blood–derived NK cells engineered to express a CD70-specific chimeric antigen receptor and an IL-15 transgene. The CAR redirects NK cells to CD70-expressing tumor cells to trigger antigen-specific NK activation and cytotoxicity (perforin/granzyme release and death receptor pathways), while IL-15 provides autocrine support for survival, proliferation, and persistence in vivo.
drug_name
CAR.70/IL15-transduced cord blood–derived NK cells
nct_id_drug_ref
NCT05703854