drug_type
RELEVANT_DRUG
intervention_type
Biologic (polyclonal antibody immunosuppressant)
drug_description
Rabbit-derived polyclonal IgG immunosuppressant that depletes and functionally modulates T lymphocytes via complement-dependent cytotoxicity, apoptosis, and Fc-mediated clearance; preferentially reduces autoreactive effector/memory T cells and may spare or promote regulatory T cells to attenuate islet autoimmunity.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Thymoglobulin
drug_category
CYTOTOXIC ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Rabbit-derived polyclonal IgG (anti-thymocyte globulin) that binds multiple T-cell surface antigens (e.g., CD2/CD3/CD4/CD8), inducing T-cell depletion via complement-dependent cytotoxicity, apoptosis, and Fc receptor–mediated clearance; preferentially reduces autoreactive effector/memory T cells while relatively sparing or promoting regulatory T cells, thereby suppressing TCR-driven and cytokine-mediated immune responses and attenuating islet autoimmunity.
drug_name
Antithymocyte Globulin (ATG; Thymoglobulin)
nct_id_drug_ref
NCT04291703