drug_type
RELEVANT_DRUG
intervention_type
Monoclonal antibody (TNF inhibitor)
drug_description
Chimeric monoclonal antibody that neutralizes TNF-α.
nci_thesaurus_concept_id
C1789
nci_thesaurus_preferred_term
Infliximab
nci_thesaurus_definition
A recombinant chimeric, mouse-human monoclonal antibody directed against tumor necrosis factor alpha (TNF-alpha), a protein involved in inflammation, cell survival, and apoptosis. Infliximab may be pro- apoptotic or anti-apoptotic, depending on cell type. (NCI04)
drug_mesh_term
Infliximab
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Chimeric monoclonal antibody that binds soluble and transmembrane TNF-alpha, blocking its interaction with TNFR1/TNFR2 and downstream NF-kappaB/MAPK signaling; suppresses pro-inflammatory cytokine activity and may induce complement/ADCC or apoptosis in TNF-alpha–expressing cells depending on context.
drug_name
Infliximab
nct_id_drug_ref
NCT06075706