drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy (CAR T cells)
drug_description
Autologous T cells engineered with a chimeric antigen receptor targeting CD19 to eliminate CD19-positive malignant B cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T cells genetically engineered to express a chimeric antigen receptor that binds CD19 on B cells, activating T-cell signaling (CD3ΞΆ with co-stimulatory domains) to mediate perforin/granzyme-dependent cytotoxicity and eliminate CD19-positive malignant B cells.
drug_name
CD19-directed CAR T cells
nct_id_drug_ref
NCT06755775