drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy (gene-modified T cells)
drug_description
Autologous T cells genetically engineered ex vivo to express a tumor‑specific T‑cell receptor, enabling antigen-specific recognition and cytotoxicity after adoptive transfer; designed for persistent gene expression.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Immunotherapy, Adoptive
drug_category
ENGINEERED TCR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T cells are genetically engineered ex vivo to express a tumor-specific T-cell receptor, enabling HLA-restricted recognition of peptide–MHC on tumor cells and TCR-mediated activation that drives cytotoxic killing (perforin/granzyme) and cytokine release; integrated viral vectors support durable TCR expression after adoptive transfer.
drug_name
T-cell receptor (TCR)–engineered T cells
nct_id_drug_ref
NCT05713214