drug_type
RELEVANT_DRUG
intervention_type
Biologic (antibody-drug conjugate)
drug_description
TROP2-targeted antibody–drug conjugate delivering a topoisomerase I inhibitor payload to TROP2-expressing tumor cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
TROP2-targeted antibody–drug conjugate that binds TROP2 on tumor cells, is internalized, and releases a topoisomerase I–inhibiting payload, causing DNA damage and apoptotic cell death (with potential bystander effect).
drug_name
SKB264 (MK-2870; sacituzumab tirumotecan)
nct_id_drug_ref
NCT05816252