drug_type
RELEVANT_DRUG
intervention_type
Monoclonal antibody (biologic drug)
drug_description
A humanized IgG1 monoclonal antibody administered subcutaneously that binds ILT7 on plasmacytoid dendritic cells, leading to Fc-mediated depletion/inhibition of pDCs and reduced type I interferon (IFN-α/β) signaling.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Monoclonal Antibodies, Humanized
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Subcutaneous
drug_mechanism_of_action
Humanized IgG1 monoclonal antibody that binds ILT7 on plasmacytoid dendritic cells and, via Fc effector functions, depletes/inhibits pDCs, reducing type I interferon (IFN-α/β) signaling and downstream inflammation.
drug_name
Daxdilimab (HZN-7734)
nct_id_drug_ref
NCT05669014