drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
Bicycle toxin conjugate targeting Nectin-4 that delivers the cytotoxic payload MMAE (a microtubule inhibitor), causing mitotic arrest and apoptosis.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
PEPTIDE DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
A bicyclic peptide (Bicycle toxin conjugate) that binds Nectin-4 on tumor cells and is internalized to release the cytotoxic payload MMAE, which inhibits microtubule polymerization, leading to mitotic arrest and apoptosis in Nectin-4–expressing cells.
drug_name
BT8009 (zelenectide pevedotin)
nct_id_drug_ref
NCT06225596