drug_type
RELEVANT_DRUG
intervention_type
Monoclonal antibody (immune checkpoint inhibitor)
drug_description
Humanized IgG1 anti-CTLA-4 monoclonal antibody immune checkpoint inhibitor that blocks CTLA-4 to restore CD28/B7 costimulation, enhance T-cell priming/expansion, and may deplete intratumoral Tregs via Fc-mediated cytotoxicity.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Humanized IgG1 anti-CTLA-4 monoclonal antibody that blocks CTLA-4 to relieve checkpoint inhibition, restoring CD28-B7 costimulation and enhancing T-cell priming and expansion; Fc-mediated effector function may deplete intratumoral regulatory T cells.
drug_name
ONC-392 (gotistobart)
nct_id_drug_ref
NCT05682443