drug_type
RELEVANT_DRUG
intervention_type
Biological (monoclonal antibody)
drug_description
Intravenous anti-MICA/MICB monoclonal antibody designed to maintain/restore MICA/B on the tumor surface and opsonize tumor cells, enhancing NKG2D-driven cytotoxicity and Fcγ receptor–mediated ADCC/ADCP by NK cells and macrophages.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
CYTOTOXIC ANTIBODY
drug_class
General immune activator
drug_delivery_route
Intravenous
drug_mechanism_of_action
Anti-MICA/MICB monoclonal antibody that maintains/restores MICA/B on tumor cells and opsonizes them, enhancing NKG2D-mediated recognition and Fcγ receptor–dependent ADCC/ADCP by NK cells and macrophages to promote tumor cell killing.
drug_name
DM919
nct_id_drug_ref
NCT06328673