drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
Monoclonal antibodies targeting CD20 on B cells; deplete malignant B cells via antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and direct apoptosis.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibodies, Monoclonal
drug_category
CYTOTOXIC ANTIBODY
drug_class
Other treatment
drug_delivery_route
Intravenous
drug_mechanism_of_action
Unconjugated anti‑CD20 IgG antibodies bind CD20 on B cells and mediate cell depletion primarily via Fc‑dependent antibody‑dependent cellular cytotoxicity (ADCC), complement‑dependent cytotoxicity (CDC), and by triggering direct apoptosis of CD20+ malignant (and normal) B cells.
drug_name
CD20-directed monoclonal antibodies (naked IgG)
nct_id_drug_ref
NCT06008691