drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
Antibody-drug conjugates targeting CD19 that internalize into B cells and release a cytotoxic payload to kill malignant cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibody-Drug Conjugates
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
An anti‑CD19 monoclonal antibody binds CD19 on B cells, is internalized, and releases an intracellular cytotoxic payload via linker cleavage, disrupting DNA/mitosis and inducing apoptosis of malignant CD19+ cells (with potential ancillary Fc‑mediated effector activity).
drug_name
CD19-directed antibody-drug conjugates (ADC)
nct_id_drug_ref
NCT06008691