drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
Bispecific antibodies that bind CD20 on B cells and CD3 on T cells to redirect T-cell cytotoxicity against CD20-positive malignant B cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibodies, Bispecific
drug_category
BISPECIFIC T ENGAGER
drug_class
Engager
drug_delivery_route
Intravenous
drug_mechanism_of_action
Bispecific antibodies that bind CD20 on B cells and CD3 on T cells, bringing T cells into close proximity with CD20+ malignant B cells to form an immunologic synapse and activate T-cell cytotoxicity (perforin/granzyme), leading to MHC-independent killing of target B cells.
drug_name
CD20×CD3 bispecific antibodies
nct_id_drug_ref
NCT06008691