drug_type
RELEVANT_DRUG
intervention_type
DNA vaccine (plasmid)
drug_description
A plasmid DNA therapeutic vaccine encoding a secreted, detoxified HPV16 E7 antigen fused to HSP70 to enhance dendritic-cell uptake and cross-presentation, priming HPV16-specific T-cell responses.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
DNA Vaccines
drug_category
GENE THERAPY
drug_class
Vaccine
drug_delivery_route
Intramuscular
drug_mechanism_of_action
Plasmid DNA vaccine encoding a secreted, detoxified HPV16 E7 antigen fused to HSP70. After delivery, host cells express and secrete E7-HSP70, which enhances dendritic-cell uptake and cross-presentation, leading to MHC I/II presentation and priming of HPV16-specific CD8+ and CD4+ T-cell responses.
drug_name
pNGVL4a-Sig/E7(detox)/HSP70 plasmid DNA vaccine
nct_id_drug_ref
NCT06508138