drug_type
RELEVANT_DRUG
intervention_type
Recombinant vaccinia viral vector vaccine
drug_description
A live recombinant vaccinia viral vector vaccine expressing HPV16 E6/E7 antigens to boost HPV16-specific cell-mediated immunity.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Recombinant Vaccines
drug_category
VIRAL VECTOR VACCINE
drug_class
Vaccine
drug_delivery_route
Intramuscular
drug_mechanism_of_action
Live recombinant vaccinia virus expressing HPV16 E6/E7 antigens. Following transient infection of antigen-presenting cells, E6/E7 are produced intracellularly and presented via MHC I and II, while vaccinia provides innate adjuvanticity (PRR activation). This boosts HPV16-specific CD8+ cytotoxic and CD4+ helper T-cell responses, enhancing cell-mediated immunity against HPV16-expressing cells.
drug_name
TA-HPV recombinant vaccinia virus
nct_id_drug_ref
NCT06508138