drug_type
RELEVANT_DRUG
intervention_type
Monoclonal antibody (biologic)
drug_description
Afucosylated human IgG1 monoclonal antibody targeting the IL-5 receptor alpha on eosinophils and basophils; blocks IL-5 signaling and induces NK cell-mediated ADCC to deplete eosinophils; administered subcutaneously for severe eosinophilic asthma.
nci_thesaurus_concept_id
C88594
nci_thesaurus_preferred_term
Benralizumab
nci_thesaurus_definition
An afucosylated, humanized monoclonal antibody against the alpha chain of the interleukin-5 receptor (IL-5Ra), with potential anti-asthmatic activity. Upon administration, benralizumab binds to IL-5Ra and elicits an antibody-directed cell cytotoxicity (ADCC) against IL-5Ra-expressing cells. This induces apoptosis in IL-5Ra-expressing cells and may reduce asthmatic episodes. IL-5Ra, expressed on both eosinophils and basophils, plays a key role in asthma.
drug_mesh_term
Benralizumab
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Subcutaneous
drug_mechanism_of_action
Afucosylated human IgG1 monoclonal antibody that binds IL-5 receptor alpha (IL-5Rα) on eosinophils and basophils, blocking IL-5 signaling and engaging FcγRIIIa on NK cells to induce ADCC-mediated depletion of eosinophils, thereby reducing type 2/eosinophilic inflammation in severe asthma.
drug_name
Benralizumab
nct_id_drug_ref
NCT05692180