drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy
drug_description
Maternal CMV-specific cytotoxic T lymphocytes used as adoptive cellular immunotherapy; generated/selected with CMV peptide pools to recognize CMV peptide–HLA complexes on infected cells and mediate antigen-specific killing via perforin/granzyme and IFN-γ, restoring antiviral immunity.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
T-Lymphocytes, Cytotoxic
drug_category
TCR SELECTED T CELLS
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Adoptively transferred maternal cytotoxic T lymphocytes selected/expanded for native TCR recognition of CMV peptide–HLA complexes on infected cells; upon engagement they mediate antigen-specific killing via perforin/granzyme release and secrete cytokines (e.g., IFN-γ), restoring CMV-specific cellular immunity without genetic engineering.
drug_name
CMV Cytotoxic T-Lymphocytes
nct_id_drug_ref
NCT05564598