A receptor-targeted oncolytic RNA virus, with potential antineoplastic and immunomodulating activities. Upon intra-tumoral administration, the oncolytic RNA virus IVX037 selectively targets specific receptors overexpressed on cancer cells, thereby allowing for selective replication in cancer cells without being able to infect and replicate in normal, healthy cells. This induces selective oncolytic virus-mediated cytotoxicity in cancer cells, which leads to cancer cell lysis. Following the lysis of infected cells, the replicated virus is released and can infect adjacent tumor cells, which both induces further tumor cell oncolysis and may beneficially alter the tumor microenvironment (TME). This may further activate both innate and adaptive immune responses against cancer cells.