drug_type
RELEVANT_DRUG
intervention_type
Drug (radiolabeled monoclonal antibody; radioimmunotherapy)
drug_description
CAIX-targeted monoclonal antibody conjugated to the beta-emitter lutetium-177; delivers localized radiation to CAIX-expressing tumor cells (radioimmunotherapy).
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
RADIOIMMUNOCONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
CAIX-targeted monoclonal antibody linked to the beta-emitter lutetium-177; binds CAIX on tumor cells and delivers localized ionizing radiation, causing DNA damage (e.g., double-strand breaks) and tumor cell death, with potential bystander effects on adjacent cells.
drug_name
177Lu-girentuximab
nct_id_drug_ref
NCT05663710