drug_type
RELEVANT_DRUG
intervention_type
monoclonal antibody (biologic)
drug_description
Monoclonal antibody targeting OX40 (CD134) intended to block OX40–OX40L signaling and/or deplete OX40-positive activated T cells to reduce T-cell activation, survival, and type 2 inflammatory cytokines in atopic dermatitis.
nci_thesaurus_concept_id
C185389
nci_thesaurus_definition
An agonistic recombinant monoclonal antibody that recognizes the co-stimulatory receptor OX40 (CD134; tumor necrosis factor receptor superfamily member 4; TNFRSF4), with potential immunostimulatory activity. Upon administration, anti-OX40 agonist monoclonal antibody BAT6026 selectively targets, binds to and activates OX40. This may induce the proliferation of memory and effector T-lymphocytes and inhibit the function of T-regulatory cells (Tregs) in the tumor microenvironment (TME). This enhances anti-tumor immune responses and prevents Tregs-mediated immune suppression. OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes and plays an essential role in T-cell activation and differentiation.
drug_mesh_term
Antibodies, Monoclonal
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Monoclonal antibody against OX40 (CD134) that blocks OX40–OX40L costimulatory signaling and can deplete OX40-positive activated T cells, thereby reducing T-cell activation, survival, and type 2 inflammatory cytokines in atopic dermatitis.
drug_name
BAT6026
nct_id_drug_ref
NCT06094179