drug_type
RELEVANT_DRUG
intervention_type
Antibody–drug conjugate
drug_description
An anti-CLDN18.2 antibody–drug conjugate that binds Claudin 18.2 on tumor cells, internalizes, and releases a topoisomerase I–inhibitor payload to induce DNA damage and apoptosis; may also engage Fc-mediated ADCC/CDC.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Anti-CLDN18.2 monoclonal antibody linked to a topoisomerase I inhibitor; binds Claudin 18.2 on tumor cells, internalizes, and releases the cytotoxic payload to cause DNA damage and apoptosis, with potential Fc-mediated ADCC/CDC.
drug_name
IBI343 (arcotatug tavatecan)
nct_id_drug_ref
NCT06238843