drug_type
RELEVANT_DRUG
intervention_type
Antibody-drug conjugate
drug_description
TROP2-directed antibody–drug conjugate carrying a topoisomerase I inhibitor payload; binds TROP2 on tumor cells, is internalized, and releases the cytotoxic payload to induce DNA damage/replication stress with a bystander effect.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
TROP2-targeted antibody–drug conjugate that binds TROP2 on tumor cells, is internalized, and releases a topoisomerase I inhibitor payload to induce DNA damage and replication stress, with a membrane-permeable bystander effect.
drug_name
Sacituzumab tirumotecan (MK-2870)
nct_id_drug_ref
NCT06312176