drug_type
RELEVANT_DRUG
intervention_type
antibody–drug conjugate (ADC)
drug_description
A Nectin-4–targeting antibody–drug conjugate (ADC) that delivers the microtubule-disrupting cytotoxic payload MMAE to tumor cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Bulumtatug fuvedotin (9MW2821) targets Nectin-4 on tumor cells; after binding and internalization, the linker is cleaved to release MMAE, which inhibits tubulin polymerization, causing G2/M arrest and apoptotic cell death (with potential bystander cytotoxicity).
drug_name
9MW2821 (Bulumtatug fuvedotin)
nct_id_drug_ref
NCT06592326