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drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy (Autologous CAR T cells)
drug_description
Autologous, second-generation, bispecific CD20/BCMA-directed chimeric antigen receptor T-cell (CAR-T) therapy. Patient T cells are gene-engineered to express a CAR recognizing CD20 and BCMA; engagement triggers T-cell activation, cytotoxic killing, and cytokine release, depleting CD20+ B cells and BCMA+ plasmablasts/long-lived plasma cells to reduce autoantibody-mediated pathology. Administered as a single IV infusion.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Immunotherapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous second-generation bispecific CD20/BCMA-directed CAR T cells. Patient T cells are engineered to express a CAR that recognizes CD20 on B cells and BCMA on plasmablasts/plasma cells; antigen binding triggers T-cell activation, cytotoxic killing, and cytokine release, leading to depletion of pathogenic B-lineage cells and reduction of autoantibody production.
drug_name
C-CAR168
nct_id_drug_ref
NCT06249438