drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
Anti-EGFR monoclonal antibody that blocks ligand binding and downstream EGFR signaling (RAS–MAPK, PI3K–AKT) and may induce antibody-dependent cellular cytotoxicity (ADCC).
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibodies, Monoclonal
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Anti-EGFR monoclonal antibody that blocks ligand binding to EGFR, shutting down downstream RAS–MAPK and PI3K–AKT signaling to inhibit tumor cell proliferation and survival; Fc domain may engage immune effector cells to mediate ADCC against EGFR-expressing cells.
drug_name
Nituzumab
nct_id_drug_ref
NCT06414577