drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy (CAR T cells)
drug_description
T cells from a newly matched donor engineered to express an anti-CD5 chimeric antigen receptor to bind CD5 on malignant T cells and trigger CAR-mediated cytotoxic killing, with anticipated on-target depletion of normal CD5+ T cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Allogeneic donor T cells engineered to express an anti-CD5 chimeric antigen receptor bind CD5 on malignant T cells, triggering CAR-mediated activation (CD3ΞΆ/costimulatory signaling), proliferation, and perforin/granzyme-dependent cytotoxic killing; on-target depletion of normal CD5+ T cells is anticipated.
drug_name
Donor-derived CD5 CAR T cells (newly matched donor)
nct_id_drug_ref
NCT06316856