drug_type
RELEVANT_DRUG
intervention_type
Monoclonal antibody (bispecific IgG1)
drug_description
Bispecific IgG1 monoclonal antibody targeting EGFR and MET; blocks EGFR/MET signaling, promotes receptor internalization/degradation, and mediates Fc-dependent cytotoxicity (ADCC/ADCP); administered IV.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
amivantamab
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Bispecific IgG1 monoclonal antibody targeting EGFR and MET; blocks EGFR/MET signaling, induces receptor internalization and degradation, and engages Fc receptors to mediate ADCC/ADCP against tumor cells.
drug_name
Amivantamab (JNJ-61186372)
nct_id_drug_ref
NCT05908734