drug_type
RELEVANT_DRUG
intervention_type
Cellular immunotherapy (autologous dendritic cell vaccine)
drug_description
Patient-derived dendritic cells pulsed ex vivo with DKK1 peptide to present the antigen and induce DKK1-specific antitumor T-cell responses in myeloma.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Cancer Vaccines
drug_category
DC VACCINE
drug_class
Vaccine
drug_delivery_route
Not specified
drug_mechanism_of_action
Autologous dendritic cells are generated ex vivo and pulsed with DKK1 peptide; after reinfusion they present DKK1 via MHC to prime DKK1-specific CD8+ and CD4+ T cells, inducing cytotoxic T-cell killing of DKK1-expressing myeloma/plasma cells and potentially anti-DKK1 antibodies, thereby generating tumor-specific immunity.
drug_name
Autologous dendritic cell DKK1 vaccine
nct_id_drug_ref
NCT03591614