drug_type
RELEVANT_DRUG
intervention_type
Antibody–drug conjugate (TROP2-directed)
drug_description
TROP2-directed antibody–drug conjugate that delivers a topoisomerase I inhibitor (DXd). Binds TROP2 on tumor cells, is internalized, and releases the cytotoxic payload to induce DNA damage and cell death (with potential bystander effect).
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Datopotamab Deruxtecan
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
TROP2-directed antibody–drug conjugate that binds TROP2 on tumor cells, is internalized, and releases the DXd topoisomerase I inhibitor payload to induce DNA damage and tumor cell death, with potential bystander effect.
drug_name
Datopotamab Deruxtecan (Dato-DXd)
nct_id_drug_ref
NCT05555732