drug_type
RELEVANT_DRUG
intervention_type
Recombinant fusion protein (SIRPα-Fc); CD47 blocker
drug_description
Recombinant SIRPα-Fc fusion protein that binds CD47 to block the CD47–SIRPα 'don't-eat-me' signal, enhancing macrophage-mediated phagocytosis and antigen presentation.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
INHIBITORY FUSION PROTEIN
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Recombinant SIRPα–Fc fusion protein that binds CD47 on tumor cells, blocking the CD47–SIRPα innate immune checkpoint to remove the “don’t‑eat‑me” signal, thereby enhancing macrophage-mediated phagocytosis and downstream antigen presentation/T‑cell priming.
drug_name
IMM01 (timdarpacept)
nct_id_drug_ref
NCT06465446