drug_type
RELEVANT_DRUG
intervention_type
Antibody-drug conjugate
drug_description
An anti-FOLR1 human IgG1 antibody-drug conjugate with a cleavable hemiasterlin payload (SC209); after FOLR1 binding and internalization, the payload inhibits tubulin polymerization, causing mitotic arrest and cell death.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibody-Drug Conjugates
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Anti-FOLR1 human IgG1 antibody-drug conjugate that binds FOLR1 on tumor cells, is internalized, and releases a cleavable hemiasterlin payload (SC209) that inhibits tubulin polymerization, inducing mitotic arrest and cell death in FOLR1-expressing cells.
drug_name
Luveltamab tazevibulin (STRO-002)
nct_id_drug_ref
NCT05870748