drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy (CAR T)
drug_description
Autologous humanized anti-CD19 CAR T-cell therapy that depletes CD19-positive B-lineage cells (naive, memory, plasmablasts) to suppress humoral alloimmunity.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Immunotherapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous humanized anti-CD19 chimeric antigen receptor T cells that bind CD19 on B-lineage cells and, upon engagement, activate cytotoxic pathways to eliminate CD19+ naive and memory B cells and plasmablasts, reducing antibody production and suppressing humoral alloimmunity.
drug_name
huCART19
nct_id_drug_ref
NCT06056102