drug_type
RELEVANT_DRUG
intervention_type
antibody-drug conjugate (ADC)
drug_description
An intravenous CD70-targeted antibody-drug conjugate (ADC) comprising an anti-CD70 monoclonal antibody linked to a topoisomerase I inhibitor payload; binds CD70 on tumor cells, is internalized, and releases the cytotoxic payload to induce DNA damage and tumor cell death.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
CD70-targeted monoclonal antibody linked to a topoisomerase I inhibitor; binds CD70 on tumor cells, is internalized, and releases the cytotoxic payload to inhibit topoisomerase I, causing DNA damage and tumor cell death.
drug_name
GEN1160 (PRO1160)
nct_id_drug_ref
NCT05721222