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drug_type
RELEVANT_DRUG
intervention_type
Biological
drug_description
An intravenous, every-2-weeks protein biologic CAR T-cell engager that binds the anti-CD19 CAR on previously infused CAR T cells and simultaneously binds antigens on malignant B cells, bridging them to form an immune synapse to reactivate and expand residual CD19-CAR T cells and redirect them to tumor cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Fusion Proteins, Bispecific
drug_category
BISPECIFIC T ENGAGER
drug_class
Engager
drug_delivery_route
Intravenous
drug_mechanism_of_action
Intravenous bispecific fusion protein that binds the anti‑CD19 CAR on previously infused CD19 CAR T cells and simultaneously binds antigens on malignant B cells, bridging them to form an immune synapse. This reactivates and expands residual CAR T cells and redirects their cytotoxicity toward B‑cell tumors.
drug_name
ALETA-001
nct_id_drug_ref
NCT06045910