drug_type
RELEVANT_DRUG
intervention_type
Antibody-drug conjugate (TROP2-directed; topoisomerase I inhibitor payload)
drug_description
TROP2-targeted antibody-drug conjugate delivering a topoisomerase I inhibitor payload; binds TROP2, internalizes, and releases cytotoxic payload causing DNA damage.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
TROP2-directed antibody–drug conjugate that binds TROP2 on tumor cells, is internalized, and releases a topoisomerase I inhibitor payload to induce DNA damage and tumor cell death.
drug_name
Sacituzumab tirumotecan (sac-TMT; MK-2870)
nct_id_drug_ref
NCT06422143