drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
Subcutaneous anti‑CD38 IgG1 monoclonal antibody that depletes CD38-positive plasma cells and immunosuppressive cells via ADCC/CDC/ADCP and augments T‑cell activity.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Daratumumab
drug_category
CYTOTOXIC ANTIBODY
drug_class
Cytotoxic protein
drug_delivery_route
Subcutaneous
drug_mechanism_of_action
Subcutaneous daratumumab is an anti‑CD38 IgG1 monoclonal antibody that binds CD38 on plasma cells and other CD38+ immunosuppressive cells, inducing cell depletion via Fc‑mediated effector functions (ADCC, CDC, ADCP) and indirectly enhancing T‑cell activity.
drug_name
Daratumumab SC
nct_id_drug_ref
NCT06100237