drug_type
RELEVANT_DRUG
intervention_type
monoclonal antibody (biologic)
drug_description
Anti-CD2 monoclonal antibody that depletes/modulates CD2+ T and NK cells and interferes with T-cell co-stimulation/adhesion.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Siplizumab
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Humanized anti-CD2 monoclonal antibody that binds CD2 on T and NK cells, blocks CD2–LFA-3 co-stimulation/adhesion, and depletes/modulates CD2+ lymphocytes via Fc-mediated effector functions (ADCC/CDC), thereby suppressing T-cell activation and proliferation.
drug_name
TCD601 (siplizumab)
nct_id_drug_ref
NCT05669001