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drug_type
RELEVANT_DRUG
intervention_type
Biological (monoclonal antibody)
drug_description
Fully human bispecific IgG4 monoclonal antibody intended to engage immune effectors to kill malignant B cells (specific targets not stated).
nci_thesaurus_concept_id
C178577
nci_thesaurus_preferred_term
Surovatamig
nci_thesaurus_definition
A human bispecific T-cell engager antibody composed of a fixed-light-chain (FLC) arm targeting the CD3 antigen found on T-lymphocytes and a heavy-chain-only (HCO) arm targeting the B-cell-specific membrane protein CD19, with potential immunostimulating and antineoplastic activities. Upon administration, surovatamig binds to both the CD3 antigen on cytotoxic T-lymphocytes (CTLs) and the CD19 antigen expressed on malignant B-cells. This activates and redirects CTLs to CD19-expressing tumor cells, resulting in CTL-mediated killing of tumor cells. CD19 is a membrane antigen that is widely expressed during B-cell development, from pro-B-cell to early plasma cell stages. The FLC arm weakly activates CD3. The HCO arm has a high affinity anti-CD19 moiety.
drug_category
BISPECIFIC T ENGAGER
drug_class
Engager
drug_delivery_route
Intravenous
drug_mechanism_of_action
Fully human bispecific IgG4 antibody that binds CD3 on T cells and CD19 on B cells, physically redirecting cytotoxic T lymphocytes to CD19+ malignant B cells to induce perforin/granzyme-mediated killing. The fixed-light-chain arm weakly activates CD3, while the heavy-chain-only arm binds CD19 with high affinity, enabling MHC-independent T-cell engagement and tumor cell lysis.
drug_name
AZD0486
nct_id_drug_ref
NCT06549595