drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy (CAR-NK)
drug_description
Genetically engineered natural killer (NK) cells expressing a chimeric antigen receptor targeting mesothelin to enable targeted cytotoxicity against mesothelin-positive ovarian epithelial carcinoma.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Natural Killer Cells
drug_category
CAR NK
drug_class
Cellular Therapy
drug_delivery_route
Not specified
drug_mechanism_of_action
Genetically engineered NK cells express a mesothelin-specific chimeric antigen receptor that binds mesothelin on tumor cells and triggers NK-cell activation, leading to targeted cytotoxicity (perforin/granzyme release and cytokine secretion) and lysis of mesothelin-positive ovarian cancer cells.
drug_name
SZ011 CAR-NK
nct_id_drug_ref
NCT05856643