drug_type
RELEVANT_DRUG
intervention_type
Monoclonal antibody (biological)
drug_description
Monoclonal antibody targeting the GD2 ganglioside on neuroblastoma cells; facilitates NK cell–mediated ADCC via CD16.
nci_thesaurus_concept_id
C155653
nci_thesaurus_definition
Any monoclonal antibody that is directed against the GD2 (GD-2) antigen.
drug_mesh_term
Antibodies, Monoclonal
drug_category
CYTOTOXIC ANTIBODY
drug_class
General immune activator
drug_delivery_route
Intravenous
drug_mechanism_of_action
Monoclonal antibody that binds the GD2 ganglioside on neuroblastoma cells; the Fc region engages FcγRIIIa (CD16) on NK cells to drive antibody-dependent cellular cytotoxicity (ADCC), and can also trigger complement-dependent cytotoxicity and macrophage antibody-dependent cellular phagocytosis, leading to tumor cell killing.
drug_name
Anti-GD2 monoclonal antibody
nct_id_drug_ref
NCT06631391