drug_type
RELEVANT_DRUG
intervention_type
Cellular immunotherapy (therapeutic cancer vaccine)
drug_description
Autologous dendritic cells ex vivo loaded with survivin peptides; administered intradermally and intravenously to prime/expand tumor-specific CD8+ and CD4+ T cells against survivin-expressing glioblastoma cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Dendritic Cell Vaccine
drug_category
DC VACCINE
drug_class
Vaccine
drug_delivery_route
Intradermal, Intravenous
drug_mechanism_of_action
Autologous dendritic cells are ex vivo loaded with survivin peptides and, after intradermal/IV administration, present survivin epitopes on MHC I/II to activate and expand survivin-specific CD8+ cytotoxic T cells and CD4+ helper T cells, driving targeted immune-mediated killing of survivin-expressing glioblastoma cells.
drug_name
Survivin-loaded dendritic cell vaccine
nct_id_drug_ref
NCT06524063