drug_type
RELEVANT_DRUG
intervention_type
Small-molecule inhibitor
drug_description
Oral small-molecule BCL-2 inhibitor that blocks anti-apoptotic BCL-2 to restore mitochondrial (intrinsic) apoptosis in malignant B cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
SMALL MOLECULE DRUG
drug_class
Inhibitor
drug_delivery_route
Oral
drug_mechanism_of_action
Oral small-molecule BCL-2 inhibitor that blocks the anti-apoptotic BCL-2 protein, promoting BAX/BAK activation and restoring mitochondrial (intrinsic) apoptosis in malignant B cells.
drug_name
ICP-248
nct_id_drug_ref
NCT06351527