drug_type
RELEVANT_DRUG
intervention_type
personalized mRNA cancer vaccine
drug_description
Therapeutic mRNA cancer vaccine encoding patient-specific neoantigens to deliver transcripts to antigen-presenting cells, driving MHC I/II presentation and priming CD8+ and CD4+ T-cell responses.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
RNA Vaccines
drug_category
mRNA VACCINE
drug_class
Vaccine
drug_delivery_route
Intravenous
drug_mechanism_of_action
Patient-specific neoantigen-encoding mRNA is delivered to antigen-presenting cells, where it is translated and processed for MHC I and II presentation, priming and expanding neoantigen-specific CD8+ cytotoxic and CD4+ helper T cells to drive adaptive antitumor immunity.
drug_name
Personalized neoantigen mRNA tumor vaccine
nct_id_drug_ref
NCT06156267