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drug_type
RELEVANT_DRUG
intervention_type
Monoclonal antibody (anti-EGFR)
drug_description
Recombinant humanized anti-EGFR monoclonal antibody that blocks EGFR signaling (MAPK/PI3K) and may induce ADCC.
nci_thesaurus_concept_id
C163981
nci_thesaurus_definition
A glycoengineered humanized version of the monoclonal antibody of cetuximab, with potential antineoplastic activity. Upon intravenous administration, pimurutamab selectively targets and binds to the extracellular domain of the epidermal growth factor receptor (EGFR), thereby preventing the activation and subsequent dimerization of the receptor. This may prevent EGFR-mediated signaling and inhibit EGFR-dependent tumor cell proliferation. In addition, the glyco-optimization promotes antibody-dependent cell-mediated cytotoxicity (ADCC). EGFR, a member of the epidermal growth factor family of extracellular protein ligands, may be overexpressed on the cell surfaces of certain tumor types.
drug_mesh_term
HLX07
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Glycoengineered humanized anti-EGFR monoclonal antibody that binds the extracellular domain of EGFR, preventing ligand-induced activation and dimerization to block downstream MAPK/PI3K signaling and inhibit tumor cell proliferation; Fc optimization enhances antibody-dependent cell-mediated cytotoxicity (ADCC) against EGFR-expressing cells.
drug_name
HLX07
nct_id_drug_ref
NCT05354700