drug_type
RELEVANT_DRUG
intervention_type
cell therapy (gene-modified)
drug_description
CIK cells transiently enhanced by mRNA modification to boost activity; retain MHC-unrestricted cytotoxicity via NKG2D with perforin/granzyme and Fas/FasL pathways; experimental arm.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Natural Killer T-Cells
drug_category
OTHER ENGINEERED IMMUNE CELL
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
mRNA-engineered cytokine-induced killer (CIK) cells that transiently boost activation and cytotoxic function while retaining MHC-unrestricted killing via NKG2D recognition of stress ligands (e.g., MICA/B, ULBPs), mediating tumor cell death through perforin/granzyme release and Fas/FasL pathways.
drug_name
mRNA-modified CIK cells (mRNA-CIK)
nct_id_drug_ref
NCT06389305