drug_type
RELEVANT_DRUG
intervention_type
Biological: broadly neutralizing monoclonal antibody (bNAb)
drug_description
A recombinant human broadly neutralizing monoclonal antibody that binds the HIV-1 Env gp120 CD4-binding site to block virus–CD4 interaction and entry; neutralizes diverse HIV-1 strains and can mediate Fc-dependent effector functions (ADCC/ADCP). The LS Fc mutations enhance FcRn binding and extend serum half-life.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Broadly Neutralizing Antibodies
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Not specified
drug_mechanism_of_action
Recombinant human broadly neutralizing monoclonal antibody that binds the HIV-1 Env gp120 CD4-binding site, blocking gp120–CD4 interaction and viral entry; neutralizes diverse HIV-1 strains and can engage Fc-dependent effector functions (ADCC/ADCP) against infected cells. LS Fc mutations enhance FcRn binding to extend serum half-life.
drug_name
3BNC117-LS
nct_id_drug_ref
NCT05300035